Section Edited by Claudia Palena, PhD, Walter Storkus, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Memory-promoting function of miR-379-5p attenuates CD8 T cell exhaustion by targeting immune checkpointsYou-Zhe Lin, Chia-Hsin Liu, Wan-Rong Wu, Ting-Yi Liao, Chuan-Chun Lee, Hong-Wei Li, Feng-Chi Chung, Yi-Chun Shen, Guan-Yu Zhuo, Liang-Chih Liu, Wei-Chung Cheng, Shao-Chun Wang
12 April 2025
Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanomaQian Sun, Nina Wang, Juliane Poelchen, Mareike Peter, Daniel Novak, Feyza Gül Özbay Kurt, Rebekka Bitsch, Huizi Wu, Yiman Wang, Sandra Pardo, Rui Han, Shibo Liu, Lidong Gong, Yuxin Zhang, Kilian Wistuba-HamprechtSee the full list of authors
9 April 2025
MHC class II-mediated spontaneous rejection of breast carcinomas expressing model neoantigensJames William Jenkins, Alvaro Peña, Sarah A Castro, Michael J Hansen, Virginia P Van Keulen, Sean T Foster, Pablo E Rios-Cruz, Joshua Yakubov, Destin T Hinson, Samuel M Olivier, Kevin D Pavelko, Sara J Felts, Aaron J Johnson, Larry R Pease
5 April 2025
Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killingSophie Guia, Aurore Fenis, Camille Baudesson De Chanville, Justine Galluso, Hakim Medjouel, Bertrand Escaliere, Angelika Modelska, Margaux Vienne, Noella Lopes, Amelie Pouchin, Benjamin Rossi, Laurent Gauthier, Sandrine Roulland, Eric Vivier, Emilie Narni-Mancinelli
31 March 2025
Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironmentWen-Ling Chen, Yong-Lin Chang, Su-Fang Lin, Ulrike Protzer, Masanori Isogawa, Hung-Chih Yang, Li-Rung Huang
26 March 2025
Orlistat facilitates immunotherapy via AKT-FOXO3a-FOXM1-mediated PD-L1 suppressionQingyun Tang, Jie Li, Lianhua Zhang, Shuo Zeng, Qiyu Bao, Weichao Hu, Lijiao He, Guiping Huang, Liting Wang, Yunyi Liu, Xiaoyan Zhao, Shiming Yang, Changjiang Hu
26 March 2025
PLS-α-GalCer: a novel targeted glycolipid therapy for solid tumorsJulian Burks, Shweta Tiwary, David M Stevens, Sarah L Skoczen, Ruvanthi N Kularatne, Stephan T Stern, Jay A Berzofsky
22 March 2025
Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancerRichard McKinnon Walsh, Joseph Ambrose, Jarrid L Jack, Austin E Eades, Bailey A Bye, Mariana Tannus Ruckert, Fanuel Messaggio, Appolinaire A Olou, Prabhakar Chalise, Dong Pei, Michael N VanSaun
22 March 2025
Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancerJulio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Amanda Heard, Prabhakar Chalise, Jeffery M Vahrenkamp, Andrea E Wilson, Cong-Xiao Liu, Gangjun Lei, Junping Wei, Hugo Cros, Hisham Mohammed, Melissa TroesterSee the full list of authors
18 March 2025
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancerJinlin Duan, Tao Chen, Qiwei Li, Yu Zhang, Ting Lu, Junyan Xue, Yang Sun, Ling Gao, Yonglong Zhang
13 March 2025