Section Edited by Claudia Palena, PhD, Walter Storkus, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Arginase-1-specific T cells target and modulate tumor-associated macrophagesEvelina Martinenaite, Inés Lecoq, Mia Aaboe-Jørgensen, Shamaila Munir Ahmad, Maria Perez-Penco, Hannah Jorinde Glöckner, Marion Chapellier, Lucía Lara de la Torre, Lars Rønn Olsen, Anne Mette Askehøj Rømer, Ayako Wakatsuki Pedersen, Mads Hald Andersen
29 January 2025
Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanomaRotem Leshem, Kieran Neil Sefton, Chun Wai Wong, I-Hsuan Lin, Dervla Tamara Isaac, Mario Niepel, Adam Hurlstone
27 January 2025
Selective expression and significance of ACKR2 in lung aerocytesFrancesca Albano, Valeria Mollica Poeta, Lucia Zotti, Alessandra Castagna, Arianna Felicetta, Alessandro Mesaglio, Elisa Zaghen, Marina Sironi, Arianna Capucetti, Rachele Di Donato, Mattia Laffranchi, Matteo Massara, Roberta Carriero, Gianluigi Condorelli, Silvano SozzaniSee the full list of authors
21 January 2025
Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokinesAnton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Tim Eiseler, Anton Wellstein, Alexander Kleger, Thomas Seufferlein, Sabine Windhorst, Yuan-Na Lin
16 January 2025
CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumorsYi Sun, Elliott Yee, Yuki Fujiwara, Kaitlyn Dickinson, Yujie Guo, Zhiwei Sun, Junyi Hu, Eduardo Davila, Richard D Schulick, Yuwen Zhu
13 January 2025
PD-1 suppresses human CD38 circulating Tfr cells and regulates humoral immunityHeng Zhang, Hui Zheng, Yanchun Wang, Cuncun Chen, Ying Tong, Suhong Xie, Xiaolu Ma, Lin Guo, Renquan Lu
11 January 2025
Utilization of primary tumor samples for cancer neoantigen discoveryVid Leko, Eric Groh, Shoshana T Levi, Amy R Copeland, Bradley Sinclair White, Billel Gasmi, Yong Li, Victoria Hill, Devikala Gurusamy, Noam Levin, Sanghyun Peter Kim, Sivasish Sindiri, Jared J Gartner, Todd D Prickett, Maria ParkhustSee the full list of authors
11 January 2025
Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathwayXiaoying Wei, Hong Wang, Huiquan Liu, Jianguo Wang, Peijie Zhou, Xiaoyang Li, Yuan He, Yan Li, Dong Han, Ting Mei, Yuwen Wang, Ziye Li, Junhao Ning, Zilong Xu, Anlin WangSee the full list of authors
7 January 2025
Differential impact of TIM-3 ligands on NK cell functionJuncheng Wang, Housaiyin Li, Aditi Kulkarni, Jennifer L Anderson, Pragati Upadhyay, Onyedikachi Victor Onyekachi, Lidia M R B Arantes, Hridesh Banerjee, Lawrence P Kane, Xin Zhang, Tullia C Bruno, Riyue Bao, Robert L Ferris, Lazar Vujanovic
7 January 2025
Targeting the NLRP3 inflammasome abrogates cardiotoxicity of immune checkpoint blockersYang Lu, Jiamin Gao, Yachen Hou, Han Yang, Dashuai Wang, Ge Zhang, Zhen Qin, Pengchong Du, Zhenwei Wang, Yunzhe Wang, Quanzhou Chen, Zhaowei Sun, Ping Li, Jinying Zhang, Junnan Tang
7 January 2025