Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Long-term mortality outcomes among immunotherapy recipients treated with dupilumab for the management of cutaneous immune-related adverse eventsSara Khattab, Guihong Wan, Suzanne Xu, Cameron Moseley, Matthew Tran, Emma Beagles, Chuck Lin, Bonnie W Leung, Marjan Azin, Ninghui Hao, Kerry L Reynolds, Shadmehr Demehri, Nicole R LeBoeuf, Yevgeniy R Semenov
12 May 2025
The cold immunological landscape of ATM-deficient cancersSonali Sinha, Victor Ng, Ardijana Novaj, Yingjei Zhu, Shu Yazaki, Xin Pei, Fatemeh Derakhshan, Fresia Pareja, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Jennifer MaSee the full list of authors
11 May 2025
Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapyAnna Sax, Peter May, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Florian Bassermann, Katja Steiger, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger
8 May 2025
Carboplatin, etoposide, atezolizumab, and bevacizumab in the first-line treatment of patients with extensive stage small-cell lung cancer: the GOIRC-01-2019 CeLEBrATE studyGiuseppe Lamberti, Karim Rihawi, Francesca Mazzoni, Ferdinando Riccardi, Alessandro Follador, Marcello Tiseo, Antonio Frassoldati, Ida Colantonio, Andrea Bonetti, Carlo Genova, Donatella Giardina, Federica Bertolini, Saverio Cinieri, Giulia Pasello, Matteo BrighentiSee the full list of authors
7 May 2025
LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunityDes C Jones, Lorraine Irving, Rebecca Dudley, Seraina Blümli, Marcin Wolny, Elisavet I Chatzopoulou, Stacy Pryts, Shreya Ahuja, D Gareth Rees, Alan M Sandercock, Saravanan Rajan, Reena Varkey, Michael Kierny, Andrew Kayserian, Kathy MulgrewSee the full list of authors
17 April 2025
Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkin’s lymphomaCharlotte Junkuhn, Phillip Schiele, Anna Luzie Walter, Frederik Hamm, Benedikt Obermayer, David Busch, Andrea Stroux, Mareike Frick, Olaf Penack, Frederik Damm, Julia Polansky, Lars Bullinger, Annette Künkele, Marco Frentsch, Il-Kang Na
9 April 2025
Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockadeMarcel Arias-Badia, Chien-Chun Steven Pai, Yee May Lwin, PeiXi Chen, Aahir Srinath, Miho Tanaka, Emily Musser, Andrew Goodearl, Jacob V Gorman, Wendy Ritacco, Lawrence Fong
2 April 2025
Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumorsKoichi Jinushi, Takuro Saito, Koji Kurose, Susumu Suzuki, Takashi Kojima, Taishi Takahara, Tomoki Makino, Tetsuya Ogawa, Hiroyoshi Nishikawa, Kazuhiro Kakimi, Shinsuke Iida, Jun Nakajima, Yuichiro Doki, Mikio Oka, Ryuzo UedaSee the full list of authors
2 April 2025
Systemic immunomodulation by irreversible electroporation versus stereotactic ablative body radiotherapy in locally advanced pancreatic cancer: the CROSSFIRE trialBart Geboers, Florentine Timmer, Danielle Vos, Hester Scheffer, Joyce Bakker, Alette Ruarus, Laurien Vroomen, Anita Stam, Sinéad Lougheed, Evelien Schouten, Robbert Puijk, Petrousjka van den Tol, Frank Lagerwaard, Jan de Vries, Anna BruynzeelSee the full list of authors
26 March 2025
mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumorsHenry G Withers, Junko Matsuzaki, Mark Long, Spencer R Rosario, Thinle Chodon, Takemasa Tsuji, Richard Koya, Li Yan, Jianming Wang, Tibor Keler, Shashikant B Lele, Emese Zsiros, Amit Lugade, Alan Hutson, Stephanie BlankSee the full list of authors
25 March 2025