Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registryAlessio Cortellini, Leonardo Brunetti, Giuseppina Rita Di Fazio, Edoardo Garbo, David J Pinato, Jarushka Naidoo, Artur Katz, Monica Loza, Joel W Neal, Carlo Genova, Scott Gettinger, So Yeon Kim, Ritujith Jayakrishnan, Talal El Zarif, Marco RussanoSee the full list of authors
4 February 2025
Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinomaThomas Eigentler, Ioannis Thomas, Igor Samoylenko, Michael Erdmann, Lucie Heinzerling, Sebastian Ochsenreither, Jürgen Krauss, Arjun Oberoi, Caroline Robert, Celeste Lebbe, Juan Martin-Liberal, Lukas Koch, Erika Richtig, Patrick Terheyden, Carsten WeishauptSee the full list of authors
4 February 2025
Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphomaClara Kolbe, Joseph Kauer, Berit Brinkmann, Peter Dreger, Wolfgang Huber, Carsten Müller-Tidow, Sascha Dietrich, Tobias Roider
30 January 2025
Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinomaShin-Yi Chung, Yi-Chen Yeh, Chien-Jung Huang, Nai-Jung Chiang, Dennis Shin-Shian Hsu, Ming-Hsien Chan, Meng-Lun Lu, Tzu-Sheng Hsu, Yi-Ping Hung, Chun-Nan Yeh, Michael Hsiao, Yu-Chan Chang, Yu-Chao Wang, Ming-Huang Chen
27 January 2025
First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignanciesAna Carneiro, Amanda Hahn, Peter Ellmark, Karin Enell Smith, Lena Schultz, Sumeet Ambarkhane, Jeffrey Yachnin, Gustav J. Ullenhag
22 January 2025
PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironmentCéline Godfroid, Jackeline Romero, Sara Labiano, Chia-Hsien Chuang, Andrea Kelemen, Tania Wyss, Vincent Roh, Grégory Verdeil, Christian Klein, Laura Codarri Deak, Pablo Umaña, Genrich V Tolstonog, Christine Trumpfheller, Marie-Catherine Vozenin, Pedro J Romero
22 January 2025
Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteriaLixing Li, Xin Xu, Wentao Wang, Peiran Huang, Lei Yu, Zhenggang Ren, Jia Fan, Jian Zhou, Lan Zhang, Zheng Wang
16 January 2025
Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumorsBlessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick McKinley, Ruslan D Novosiadly, Sarina A Piha-Paul
16 January 2025
Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapyJim Middelburg, Gaby Schaap, Marjolein Sluijter, Katy Lloyd, Vitalijs Ovcinnikovs, Janine Schuurman, Sjoerd H van der Burg, Kristel Kemper, Thorbald van Hall
11 January 2025
First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancerNehal J Lakhani, Daphne Stewart, Debra L Richardson, Lauren E Dockery, Linda Van Le, Justin Call, Fatima Rangwala, Guanfang Wang, Bo Ma, Simon Metenou, Jade Huguet, Elliot Offman, Lini Pandite, Erika Hamilton
11 January 2025