Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapyYanyang Nan, Yu Bai, Xiaozhi Hu, Kaicheng Zhou, Tao Wu, An Zhu, Mengyang Li, Zihan Dou, Zhonglian Cao, Xumeng Zhang, Shuwen Xu, Yuanzhen Zhang, Jun Lin, Xian Zeng, Jiajun FanSee the full list of authors
3 September 2024
Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironmentBrenda C O'Connell, Charley Hubbard, Nora Zizlsperger, Donna Fitzgerald, Jeffrey L Kutok, Judith Varner, Robert Ilaria, Jr, Melody A Cobleigh, Dejan Juric, Kate H R Tkaczuk, Anthony Elias, Arielle Lee, Shaker Dakhil, Erika HamiltonSee the full list of authors
30 August 2024
Nivolumab maintenance improves overall survival of patients with advanced melanoma who experience severe immune-related adverse events on nivolumab plus ipilimumabAnna K Maloney, Anita Giobbie-Hurder, Nikita Katukota, Miklos C Fogarasi, Patrick A Ott, F Stephen Hodi, Tamara A Sussman, Ann W Silk, Rizwan Haq, David Liu, Megan Insco, Elizabeth I Buchbinder
28 August 2024
Safety and tolerability of immune checkpoint inhibitors in people with HIV infection and cancer: insights from the national prospective real-world OncoVIHAC ANRS CO24 cohort studyLambert Assoumou, Raghiatou Baldé, Christine Katlama, Baptiste Abbar, Pierre Delobel, Thierry Allegre, Armelle Lavole, Alain Makinson, Olivia Zaegel-Faucher, Laurent Greillier, Cathia Soulie, Marianne Veyri, Mathilde Bertheau, Michèle Algarte Genin, Séverine GibowskiSee the full list of authors
22 August 2024
An IL-7 fusion protein targeting EDA fibronectin upregulates TCF1 on CD8+ T-cells, preferentially accumulates to neoplastic lesions, and boosts PD-1 blockadeCesare Di Nitto, Domenico Ravazza, Ettore Gilardoni, Thomas Look, Miaomiao Sun, Eleonora Prodi, Vlad Moisoiu, Christian Pellegrino, Markus G. Manz, Emanuele Puca, Michael Weller, Tobias Weiss, Dario Neri, Roberto De Luca
13 August 2024
Epithelium/imcDC2 axis facilitates the resistance of neoadjuvant anti-PD-1 in human NSCLCYongyuan Chen, Zheyu Shao, Zhixing Hao, Zhongwei Xin, Xiaoke Chen, Lijian Huang, Di Chen, Mingjie Lin, Qinyuan Liu, Xia Xu, Jinfan Li, Dang Wu, Jun Yan, Ying Chai, Pin Wu
12 August 2024
Five-year follow-up of neoadjuvant PD-1 inhibitor (sintilimab) in non-small cell lung cancerBolun Zhou, Fan Zhang, Wei Guo, Shuhang Wang, Ning Li, Bin Qiu, Liang Zhao, Jian Li, Kang Shao, Qi Xue, Fang Lv, Shugeng Gao
12 August 2024
Randomized, open-label, phase 2 study of nivolumab plus ipilimumab or nivolumab monotherapy in patients with advanced or metastatic solid tumors of high tumor mutational burdenMichael Schenker, Mauricio Burotto, Martin Richardet, Tudor-Eliade Ciuleanu, Anthony Gonçalves, Neeltje Steeghs, Patrick Schoffski, Paolo A Ascierto, Michele Maio, Iwona Lugowska, Lorena Lupinacci, Alexandra Leary, Jean-Pierre Delord, Julieta Grasselli, David S P TanSee the full list of authors
6 August 2024
Phase I studies of davoceticept (ALPN-202), a PD-L1-dependent CD28 co-stimulator and dual PD-L1/CTLA-4 inhibitor, as monotherapy and in combination with pembrolizumab in advanced solid tumors (NEON-1 and NEON-2)Diwakar Davar, Ludimila Cavalcante, Nehal Lakhani, Justin Moser, Michael Millward, Meredith McKean, Mark Voskoboynik, Rachel E Sanborn, Jaspreet S Grewal, Ajita Narayan, Amita Patnaik, Justin F Gainor, Mario Sznol, Amanda Enstrom, Lori BlanchfieldSee the full list of authors
3 August 2024
Exploring markers of immunoresponsiveness in papillary thyroid carcinoma and future treatment strategiesAtish Mohanty, Michelle Afkhami, Amanda Reyes, Rebecca Pharaon, Holly Yin, Haiqing Li, Dana Do, Diana Bell, Arin Nam, Sue Chang, Thomas Gernon, Robert Kang, Arya Amini, Sagus Sampath, Prakash KulkarniSee the full list of authors
29 July 2024