Immunosuppression

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment
Oscar Badillo-Godinez, Jenni Niemi, Liam Helfridsson, Shokoufeh Karimi, Mohanraj Ramachandran, Hitesh Bhagavanbhai Mangukiya, Sven Nelander, Mats Hellström

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011548; DOI: 10.1136/jitc-2025-011548
Mending the divide: integrating opioid analgesia and immunotherapy for optimal cancer care
Celia DeJohn, Emese Zsiros

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011644; DOI: 10.1136/jitc-2025-011644
Targeting nerve growth factor: an Achilles’ heel for tumors?
Elizabeth Repasky, Hemn Mohammadpour

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011609; DOI: 10.1136/jitc-2025-011609
Utilization of exosome-based therapies to augment anti-PD-1/PD-L1 therapies
John S. Wang, Samer Yassin, Adam Y. Lin

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010603; DOI: 10.1136/jitc-2024-010603
Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35
Juanjuan Wang, Yang Hao, Yazheng Yang, Yuan Zhang, Chen Xu, Rongcun Yang

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011155; DOI: 10.1136/jitc-2024-011155
Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma
Qian Sun, Nina Wang, Juliane Poelchen, Mareike Peter, Daniel Novak, Feyza Gül Özbay Kurt, Rebekka Bitsch, Huizi Wu, Yiman Wang, Sandra Pardo, Rui Han, Shibo Liu, Lidong Gong, Yuxin Zhang, Kilian Wistuba-Hamprecht, Viktor Umansky, Jochen Sven Utikal

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010352; DOI: 10.1136/jitc-2024-010352
PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy
Shiyu Chen, Zheyi Chen, Bingqian Zhou, Yongyu Chen, Yiren Huang, Jian Cao, Lisong Shen, Yingxia Zheng

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011299; DOI: 10.1136/jitc-2024-011299
β-blocker suppresses both tumoral sympathetic neurons and perivascular macrophages during oncolytic herpes virotherapy
Konstantina Kyritsi, Rafal Pacholczyk, Eugene Douglass, Miao Yu, Hui Fang, Gang Zhou, Balveen Kaur, Qin Wang, David H Munn, Bangxing Hong

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011322; DOI: 10.1136/jitc-2024-011322
Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer
Julio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Amanda Heard, Prabhakar Chalise, Jeffery M Vahrenkamp, Andrea E Wilson, Cong-Xiao Liu, Gangjun Lei, Junping Wei, Hugo Cros, Hisham Mohammed, Melissa Troester, Charles Perou, Mary A Markiewicz, Jason Gertz, Justin M Balko, Zachary Conrad Hartman, Christy R Hagan

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010179; DOI: 10.1136/jitc-2024-010179
Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8⁺ T cells
Kayoung Shin, Min Park, Seoho Kim, Haejong Lee, Yuseong Lee, Jongil Kim, Suyoun Park, Jisoo Kim, Kyungwha Lee, Chong Woo Park, Ji-Hyun Kim, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Sanghee Lee, Young Min Oh, Wonjae Lee, Yaein Amy Shim, Young-Gyu Cho, Junsik Park, Jung-Yun Lee, Young Jun Koh, Kook Hwan Kim, Myoung Ho Jang

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e008594; DOI: 10.1136/jitc-2023-008594

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