Tumor microenvironment - TME

Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment
Brenda C O'Connell, Charley Hubbard, Nora Zizlsperger, Donna Fitzgerald, Jeffrey L Kutok, Judith Varner, Robert Ilaria, Melody A Cobleigh, Dejan Juric, Kate H R Tkaczuk, Anthony Elias, Arielle Lee, Shaker Dakhil, Erika Hamilton, Hatem Soliman, Stephane Peluso

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (8) e009160; DOI: 10.1136/jitc-2024-009160
NKG2C/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastoma
Olaya de Dios, M Angeles Ramírez-González, Irene Gómez-Soria, Berta Segura-Collar, Juliana Manosalva, Diego Megías, Carlos E De Andrea, Leticia Fernández-Rubio, Aurelio Hernández-Laín, Juan M Sepúlveda-Sánchez, Maria E Rodriguez-Ruiz, Ángel Pérez-Núñez, Derek A Wainwright, Ricardo Gargini, Pilar Sánchez-Gómez

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (8) e009210; DOI: 10.1136/jitc-2024-009210
Immune modulatory microRNAs in tumors, their clinical relevance in diagnosis and therapy
Christoforos Vaxevanis, Michael Bachmann, Barbara Seliger

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (8) e009774; DOI: 10.1136/jitc-2024-009774
POSTN⁺ cancer-associated fibroblasts determine the efficacy of immunotherapy in hepatocellular carcinoma
Hao Wang, Yuan Liang, Zheng Liu, Rui Zhang, Jiashuo Chao, Mingming Wang, Mu Liu, Lei Qiao, Zhengfeng Xuan, Haitao Zhao, Ling Lu

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e008721; DOI: 10.1136/jitc-2023-008721
TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment
Fadi Azar, Jules Deforges, Christelle Demeusoit, Patricia Kleinpeter, Christelle Remy, Nathalie Silvestre, Johann Foloppe, Laetitia Fend, Clémentine Spring-Giusti, Eric Quéméneur, Jean-Baptiste Marchand

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009302; DOI: 10.1136/jitc-2024-009302
ImmunoPET imaging of LAG-3 expression in tumor microenvironment with ⁶⁸Ga-labelled cyclic peptides tracers: from bench to bedside
Ming Zhou, Bei Chen, Chenxi Lu, Jinhui Yang, Peng Liu, Xiaobo Wang, Shuo Hu

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009153; DOI: 10.1136/jitc-2024-009153
Immune cell topography of head and neck cancer
Tara Muijlwijk, Dennis N L M Nijenhuis, Sonja H Ganzevles, Fatima Ekhlas, Carmen Ballesteros-Merino, Laura A N Peferoen, Elisabeth Bloemena, Bernard A Fox, Jos B Poell, C René Leemans, Ruud H Brakenhoff, Rieneke van de Ven

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009550; DOI: 10.1136/jitc-2024-009550
Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myeloid-derived suppressor cells and control of liver metastases
Chandra C Ghosh, Lauren Cournoyer, Yujia Liu, Alizee Ballarin, Ilan B Layman, Jason LaPorte, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha, Prajna Guha, Steven C Katz, Diwakar Davar

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e008837; DOI: 10.1136/jitc-2024-008837
Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma
Yang Chen, Yu Zhou, Ran Ren, Yu Chen, Juan Lei, Yongsheng Li

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e008811; DOI: 10.1136/jitc-2024-008811
Extensive-stage small-cell lung cancer in patients receiving atezolizumab plus carboplatin–etoposide: stratification of outcome based on a composite score that combines gene expression profiling and immune characterization of microenvironment
Anna Tosi, Martina Lorenzi, Paola Del Bianco, Anna Roma, Alberto Pavan, Antonio Scapinello, Maria Vittoria Resi, Laura Bonanno, Stefano Frega, Fiorella Calabrese, Valentina Guarneri, Antonio Rosato, Giulia Pasello

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e008974; DOI: 10.1136/jitc-2024-008974

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