Tumor microenvironment - TME

B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma
Qian Zhong, Hongying Hao, Shu Li, Yongling Ning, Hong Li, Xiaoling Hu, Kelly M McMasters, Jun Yan, Chuanlin Ding

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009861; DOI: 10.1136/jitc-2024-009861
Degradation of PARP1 by MARCHF3 in tumor cells triggers cCAS-STING activation in dendritic cells to regulate antitumor immunity in hepatocellular carcinoma
Jun Cao, Bingbing Su, Chi Zhang, Rui Peng, Daoyuan Tu, Qiangwei Deng, Guoqing Jiang, Shengjie Jin, Qian Wang, Dou-Sheng Bai

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010157; DOI: 10.1136/jitc-2024-010157
Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy
Tracee L McMiller, Sepideh Besharati, Mark Yarchoan, Qingfeng Zhu, Keziban Ünsal-Kaçmaz, Ke Xu, Junghwa Lee, Feriyl Bhaijee, Logan L Engle, Janis M Taube, Alan E Berger, Robert A Anders, Suzanne L Topalian

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010201; DOI: 10.1136/jitc-2024-010201
TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion
Anais Debesset, Caroline Pilon, Sylvain Meunier, Orianne Cuelenaere-Bonizec, Wilfrid Richer, Allan Thiolat, Claire Houppe, Matteo Ponzo, Jeanne Magnan, Jonathan Caron, Pamela Caudana, Jimena Tosello Boari, Sylvain Baulande, Nhu Han To, Benoit Laurent Salomon, Eliane Piaggio, Ilaria Cascone, José Laurent Cohen

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e008898; DOI: 10.1136/jitc-2024-008898
Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer
Shipra Gandhi, Ronald T Slomba, Cayla Janes, Victoria Fitzpatrick, Janine Miller, Kristopher Attwood, Giorgio Ioannou, Sinem Ozbey, Igor De Souza, Vladimir Roudko, Prasanna Kumar, Suresh Kalathil, Kathleen M Kokolus, Jianming Wang, Eduardo Cortes Gomez, Kazuaki Takabe, Stephen Edge, Jessica Young, Helen Cappuccino, Mateusz Opyrchal, Tracey O’Connor, Ellis G Levine, Sacha Gnjatic, Pawel Kalinski

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010058; DOI: 10.1136/jitc-2024-010058
WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy
Shaoqing Liu, Shiguang Yang, Min Xu, Qiang Zhou, Jialei Weng, Zhiqiu Hu, Minghao Xu, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Mien-Chie Hung, Ning Ren, Chenhao Zhou

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010422; DOI: 10.1136/jitc-2024-010422
Pancreatic cancer is feeling the heat
Saumya Y Maru, Elizabeth M Jaffee

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e010124; DOI: 10.1136/jitc-2024-010124
TGF-β trap of AdAPT-001 turns up the heat on tumors and turns down checkpoint blocker resistance
Tony R Reid, Bryan Oronsky, Jeannie Williams, Scott Caroen, Anthony Conley

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e009613; DOI: 10.1136/jitc-2024-009613
Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma
Keun Bon Ku, Chae Won Kim, Yumin Kim, Byeong Hoon Kang, Jeongwoo La, In Kang, Won Hyung Park, Stephen Ahn, Sung Ki Lee, Heung Kyu Lee

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e009449; DOI: 10.1136/jitc-2024-009449
Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8⁺ T cells
Da Jiang, Aiqi Huang, Bai-Xi Zhu, Jiangling Gong, Yong-Hao Ruan, Xing-Chen Liu, Limin Zheng, Yan Wu

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e010148; DOI: 10.1136/jitc-2024-010148

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