Section Edited by Aude Chapuis, MD and Marcela V. Maus, MD, PhD
Immune cell therapies and cell engineering approaches, new targets, novel functionalities, clinical trial results, correlative studies in patients who have received cell-based therapies, novel engineering strategies (molecular switches, conditional expression, logic gating), gene-edited cells to knock out or knock in novel functions, synthetic gene circuits. Includes pre-clinical animal modeling (small and large) and clinical trials.
Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editingMinjing Wang, Joshua B Krueger, Alexandria K Gilkey, Erin M Stelljes, Mitchell G Kluesner, Emily J Pomeroy, Joseph G Skeate, Nicholas J Slipek, Walker S Lahr, Patricia N Claudio Vázquez, Yueting Zhao, Jason B Bell, Kendell Clement, Ella J Eaton, Kanut LaoharaweeSee the full list of authors
7 May 2025
BCL-2 mutant B7H6-CAR-T cells synergized with venetoclax for treating small cell lung cancerHuihui Zhang, Liliang Xia, Wendi Xuzhang, Ziming Li, Junshi Zhang, Fanlin Li, Chen Cheng, Jiawen Wang, Xincheng Zong, Xuanming Yang, Shun Lu
7 May 2025
PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activationXinxin Xiong, Danyang Wang, Liping Xu, Siyu Chen, Jingjing He, Xiaomin Zhang, Ziqian Fang, Jianeng Zhang, Wende Li, Penghui Zhou
7 May 2025
Development and optimization of Eva1 (MPZL2) targeting chimeric antigen receptor T cellsMasahide Osaki, Seitaro Terakura, Shiho Hirano, Takuma Iwasa, Kanako C Hatanaka, Yutaka Hatanaka, Masaki Sunagawa, Toshio Kokuryo, Yoshitaka Adachi, Yuki Takeuchi, Ryo Hanajiri, Chie Sakanaka, Makoto Murata, Tomoki Ebata, Hitoshi Kiyoi
7 May 2025
CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progressionJavier Arroyo-Ródenas, Aida Falgas, Laura Díez-Alonso, Alba Martinez-Moreno, Heleia Roca-Ho, Francisco J. Gil-Etayo, Alba Pérez-Pons, Óscar Aguilar-Sopeña, Miriam Velasco-Sidro, Marina Gómez-Rosel, Beatriz Jiménez-Matías, Guillermo Muñoz-Sánchez, Yedra Pacheco, Clara Bravo-Martín, Ángel Ramírez-FernándezSee the full list of authors
30 April 2025
Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapyArne Van der Vreken, Fabien Thery, Chenggong Tu, Kevin Mwangi, Sofie Meulewaeter, Lien De Beck, Edith Janssens, Kim De Veirman, Karin Vanderkerken, Elke De Bruyne, Lorenzo Franceschini, Francis Impens, Rein Verbeke, Ine Lentacker, Eline MenuSee the full list of authors
29 April 2025
CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activityKerry A Whalen, Catherine C Henry, Naveen K Mehta, Kavya Rakhra, Safak Yalcin, Kristan Meetze, Neil W Gibson, Patrick A Baeuerle, Jennifer S Michaelson
23 April 2025
MARC, a novel modular chimeric antigen receptor, improves T cell-based cancer immunotherapies by preventing early T cell exhaustion and enhancing persistenceMargaux Tual, Angélique Bellemare-Pelletier, Susan Moore, Delphine Guipouy, Negar Farzam-Kia, Leila Jafarzadeh, Jordan Quenneville, Benoit Barrette, Marc K Saba-El-Leil, Jean-Sebastien Delisle, Etienne Gagnon
20 April 2025
T-bet overexpression enhances CAR T cell effector functions and antigen sensitivityJennifer M Cimons, Kole R DeGolier, Samuel D Burciaga, Michael C Yarnell, Amanda J Novak, Amalia M Rivera-Reyes, M. Eric Kohler, Terry J Fry
17 April 2025
Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapyEnoch Tin, Ismat Khatri, Karen Fang, Yoosu Na, Michele Nawata, Juan Arteaga, Mark D Minden, Sergio Rutella, Jongbok Lee, Li Zhang
17 April 2025