Tumor Microenvironment

Mending the divide: integrating opioid analgesia and immunotherapy for optimal cancer care
Celia DeJohn, Emese Zsiros

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011644; DOI: 10.1136/jitc-2025-011644
Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression
Ik-Hwan Han, Ilseob Choi, Hongseo Choi, Soyoung Kim, Chanmi Jeong, Juwon Yang, Yingying Cao, Jeongyoon Choi, Heekyung Lee, Jin Sun Shin, Hye Duck Yeom, Eun-Ji Lee, Nari Cha, Hyemin Go, Se Eun Lim, Songah Chae, Won-Jun Lee, Minjin Kwon, Hongsung Kim, Hyojung Choi, Sehyun Pak, Namgyeong Park, Eunbin Ko, Deok-Sang Hwang, Junho H Lee, Hwan-Suck Chung, Seong Ho Kang, Hyunsu Bae

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011422; DOI: 10.1136/jitc-2024-011422
PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy
Shiyu Chen, Zheyi Chen, Bingqian Zhou, Yongyu Chen, Yiren Huang, Jian Cao, Lisong Shen, Yingxia Zheng

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011299; DOI: 10.1136/jitc-2024-011299
Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer
Oladapo O Yeku, Minal Barve, Winston W Tan, Judy Wang, Amita Patnaik, Patricia LoRusso, Debra L Richardson, Abdul Rafeh Naqash, Sarah K Lynam, Siqing Fu, Michael Gordon, Joleen Hubbard, Shivaani Kummar, Christos Kyriakopoulos, Afshin Dowlati, Marc Chamberlain, Ira Winer

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010959; DOI: 10.1136/jitc-2024-010959
Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma
Pengpeng Zhang, Dingli Wang, Guangyao Zhou, Shuai Jiang, Ge Zhang, Lianmin Zhang, Zhenfa Zhang

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e010787; DOI: 10.1136/jitc-2024-010787
FAP-targeted radioligand therapy with ⁶⁸Ga/¹⁷⁷Lu-DOTA-2P(FAPI)₂ enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy
Jianhao Chen, Yangfan Zhou, Yizhen Pang, Kaili Fu, Qicong Luo, Long Sun, Hua Wu, Qin Lin, Guoqiang Su, Xiaoyuan Chen, Liang Zhao, Haojun Chen

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010212; DOI: 10.1136/jitc-2024-010212
Differential impact of TIM-3 ligands on NK cell function
Juncheng Wang, Housaiyin Li, Aditi Kulkarni, Jennifer L Anderson, Pragati Upadhyay, Onyedikachi Victor Onyekachi, Lidia M R B Arantes, Hridesh Banerjee, Lawrence P Kane, Xin Zhang, Tullia C Bruno, Riyue Bao, Robert L Ferris, Lazar Vujanovic

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010618; DOI: 10.1136/jitc-2024-010618
Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma
Xiyu Song, Yumeng Zhu, Wenwen Geng, Jianhua Jiao, Hongjiao Liu, Ruo Chen, Qian He, Lijuan Wang, Xiuxuan Sun, Weijun Qin, Jiejie Geng, Zhinan Chen

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010183; DOI: 10.1136/jitc-2024-010183
CAR T cells secreting NGF-neutralizing scFv enhance efficacy in clear cell renal cell carcinoma by relieving immunosuppression through immunosympathectomy
Peiwei Yang, Xi Chen, Fan Yu, Lan Wang, Meng Li, Zongke Bai, Hanmei Xu

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009910; DOI: 10.1136/jitc-2024-009910
Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma
Lianmin Zhang, Yanan Cui, Guangyao Zhou, Zhenfa Zhang, Pengpeng Zhang

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e010008; DOI: 10.1136/jitc-2024-010008

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