Combination Therapy

Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines
Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Tim Eiseler, Anton Wellstein, Alexander Kleger, Thomas Seufferlein, Sabine Windhorst, Yuan-Na Lin

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010579; DOI: 10.1136/jitc-2024-010579
Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumors
Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick McKinley, Ruslan D Novosiadly, Sarina A Piha-Paul

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010013; DOI: 10.1136/jitc-2024-010013
Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy
Jim Middelburg, Gaby Schaap, Marjolein Sluijter, Katy Lloyd, Vitalijs Ovcinnikovs, Janine Schuurman, Sjoerd H van der Burg, Kristel Kemper, Thorbald van Hall

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010331; DOI: 10.1136/jitc-2024-010331
HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAF^V600E-mutant microsatellite stable colorectal cancer
Zhuang Sun, Mengyuan Shi, Jinhong Xia, Xin Li, Nan Chen, Hanyang Wang, Zhaoya Gao, Jinying Jia, Peng Yang, Dengbo Ji, Jin Gu

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010460; DOI: 10.1136/jitc-2024-010460
CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment
Haiyan Xu, Shengbai Xue, Yang Sun, Jingyu Ma, Shumin Li, Yanling Wang, Tiebo Mao, Weiyu Ge, Ming Yue, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui, Xiaofei Zhang, Li Cai, Yu Wang, Liwei Wang

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010029; DOI: 10.1136/jitc-2024-010029
Local cell therapy using CCL19-expressing allogeneic mesenchymal stem cells exerts robust antitumor effects by accumulating CD103⁺ IL-12-producing dendritic cells and priming CD8⁺ T cells without involving draining lymph nodes
Yuichi Iida, Mamoru Harada

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009683; DOI: 10.1136/jitc-2024-009683
Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
Jing Zhao, Shichuan Hu, Zhongbing Qi, Xianglin Xu, Xiangyu Long, Anliang Huang, Jiyan Liu, Ping Cheng

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009768; DOI: 10.1136/jitc-2024-009768
Genetic and therapeutic heterogeneity shape the baseline and longitudinal immune ecosystem of ovarian clear cell carcinoma
Siyu Xia, Lihua Chen, Min Yu, Jiana Li, Jiaxin Chen, Fei Xu, Mengdong Ni, Chaohua Liu, Xiaohua Wu, Xiaojun Chen, Jiajia Li

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010069; DOI: 10.1136/jitc-2024-010069
Type I MET inhibitors cooperate with PD-1 blockade to promote rejection of hepatocellular carcinoma
Ricardo DeAzevedo, Madeline Steiner, Broderick X Turner, Arthur Liu, Sherwin Newton, Joanna Schmidt, Rachel Fleming, Angelica Tolentino, Ahmed O Kaseb, Michael A Curran

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e009690; DOI: 10.1136/jitc-2024-009690
Pancreatic cancer is feeling the heat
Saumya Y Maru, Elizabeth M Jaffee

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e010124; DOI: 10.1136/jitc-2024-010124

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