Combination Therapy

Combinatorial treatment with upadacitinib abrogates systemic toxicity of a tumor-targeted IL-2 fusion protein
Giulia Rotta, Eleonora Prodi, Frauke Seehusen, Matilde Bocci, Francesco Prisco, Ettore Gilardoni, Claudia Comacchio, Cornelia Halin, Emanuele Puca, Dario Neri, Sheila Dakhel Plaza

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e010831; DOI: 10.1136/jitc-2024-010831
Carboplatin, etoposide, atezolizumab, and bevacizumab in the first-line treatment of patients with extensive stage small-cell lung cancer: the GOIRC-01-2019 CeLEBrATE study
Giuseppe Lamberti, Karim Rihawi, Francesca Mazzoni, Ferdinando Riccardi, Alessandro Follador, Marcello Tiseo, Antonio Frassoldati, Ida Colantonio, Andrea Bonetti, Carlo Genova, Donatella Giardina, Federica Bertolini, Saverio Cinieri, Giulia Pasello, Matteo Brighenti, Elisa Andrini, Michele Tognetto, Luca Boni, Andrea Ardizzoni

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e010694; DOI: 10.1136/jitc-2024-010694
Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects
Michela Capello, Angelica Sette, Theo Plantinga, Craig J Thalhauser, Vanessa M Spires, Kristina B Nürmberger, Jordan M Blum, Brandon W Higgs, Patricia Garrido Castro, Christina Yu, Carol Costa Sa, Sina Fellermeier-Kopf, Saskia M Burm, Kristin Strumane, Aras Toker, Andrea Imle, Bruna de Andrade Pereira, Alexander Muik, Tahamtan Ahmadi, Özlem Türeci, Mark Fereshteh, Ugur Sahin, Maria Jure-Kunkel, Nora Pencheva

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011377; DOI: 10.1136/jitc-2024-011377
Topical TLR7 agonist and radiotherapy in patients with metastatic breast cancer
Sylvia Adams, Sandra Demaria, Darawan Rinchai, Ena Wang, Yelena Novik, Ruth Oratz, Maria Fenton-Kerimian, Pascale G Levine, Xiaochun Li, Francesco Marincola, Ping Jin, David Stroncek, Judith Goldberg, Davide Bedognetti, Silvia Chiara Formenti

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e011173; DOI: 10.1136/jitc-2024-011173
Microbial Ecosystem Therapeutics 4 (MET4) elicits treatment-specific IgG responses associated with changes in gut microbiota in immune checkpoint inhibitor recipients with advanced solid tumors
Matthew K Wong, Giselle M Boukhaled, Eric Armstrong, Rachel Liu, Alya A Heirali, Noelle R Yee, Jinny Tsang, Pavlina Spiliopoulou, Pierre H H Schneeberger, Ben X Wang, Kyla Cochrane, Keith Sherriff, Emma Allen-Vercoe, Lillian L Siu, Anna Spreafico, Bryan Coburn

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010681; DOI: 10.1136/jitc-2024-010681
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer
Lisha Li, Lei Zhao, Diwei Zhou, Yuanhang Yu, Peiyi Zhang, Jinge Zheng, Zhenyu Lin, Dandan Yu, Jinghua Ren, Jing Zhang, Pengfei Zhou, Dejun Zhang, Tao Zhang

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e010000; DOI: 10.1136/jitc-2024-010000
Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy in patients with melanoma from RELATIVITY-020
Paolo A Ascierto, Hao Tang, Sonia Dolfi, Marta Nyakas, Inge Marie Svane, Eva Muñoz-Couselo, Jean Jacques Grob, Carlos Alberto Gomez-Roca, Vanna Chiarion-Sileni, Katriina Peltola, James Larkin, Ignacio Melero, Margaret Callahan, Reinhard Dummer, Patrick Djidel, Deepti Warad, Diane Reusser-Wolf, Evan J Lipson, Charlie Garnett-Benson

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e009773; DOI: 10.1136/jitc-2024-009773
CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors
Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm, Megen C Wittling, Chrystal Paulos, Mary Jo Turk, Yina H Huang

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e009994; DOI: 10.1136/jitc-2024-009994
Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma
Clara Kolbe, Joseph Kauer, Berit Brinkmann, Peter Dreger, Wolfgang Huber, Carsten Müller-Tidow, Sascha Dietrich, Tobias Roider

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e009245; DOI: 10.1136/jitc-2024-009245
PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment
Céline Godfroid, Jackeline Romero, Sara Labiano, Chia-Hsien Chuang, Andrea Kelemen, Tania Wyss, Vincent Roh, Grégory Verdeil, Christian Klein, Laura Codarri Deak, Pablo Umaña, Genrich V Tolstonog, Christine Trumpfheller, Marie-Catherine Vozenin, Pedro J Romero

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e009832; DOI: 10.1136/jitc-2024-009832

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