Adenosine

Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8⁺ T cells
Kayoung Shin, Min Park, Seoho Kim, Haejong Lee, Yuseong Lee, Jongil Kim, Suyoun Park, Jisoo Kim, Kyungwha Lee, Chong Woo Park, Ji-Hyun Kim, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Sanghee Lee, Young Min Oh, Wonjae Lee, Yaein Amy Shim, Young-Gyu Cho, Junsik Park, Jung-Yun Lee, Young Jun Koh, Kook Hwan Kim, Myoung Ho Jang

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e008594; DOI: 10.1136/jitc-2023-008594
Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation
Fei Sun, Fangzhen Yao, Chunting Zeng, Yang Zhao, Bishan Liang, Shaowei Li, Yawen Wang, Qijing Wu, Yulu Shi, Zhiqi Yao, Jiao Wang, Yu Jiang, Chunhui Gu, Qiong Huang, Wangjun Liao, Na Huang, Chunlin Wang, Xiaoxiang Rong, Jing Wu, Yujing Tan, Jianjun Peng, Yong Li, Min Shi

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e010126; DOI: 10.1136/jitc-2024-010126
First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial
Alex De Caluwe, Emanuela Romano, Philip Poortmans, Andrea Gombos, Elisa Agostinetto, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Ligia Craciun, Isabelle Veys, Denis Larsimont, Marianne Paesmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Martine Piccart-Gebhart, Michail Ignatiadis, Laurence Buisseret

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007279; DOI: 10.1136/jitc-2023-007279
Increased interleukin-6/C-reactive protein levels are associated with the upregulation of the adenosine pathway and serve as potential markers of therapeutic resistance to immune checkpoint inhibitor-based therapies in non-small cell lung cancer
Abdul Rafeh Naqash, Justin D McCallen, Emma Mi, Sanna Iivanainen, Mona A Marie, Daria Gramenitskaya, James Clark, Jussi Pekka Koivunen, Shravanti Macherla, Sweta Jonnalagadda, Shanker Polsani, Rahim Ali Jiwani, Maida Hafiz, Mahvish Muzaffar, Leonardo Brunetti, Chipman R G Stroud, Paul R Walker, Kun Wang, Youngmin Chung, Eytan Ruppin, Se-Hoon Lee, Li V Yang, David J Pinato, Joo Sang Lee, Alessio Cortellini

Journal for ImmunoTherapy of Cancer Oct 2023, 11 (10) e007310; DOI: 10.1136/jitc-2023-007310
Phase 1 first-in-human study of dalutrafusp alfa, an anti–CD73-TGF-β-trap bifunctional antibody, in patients with advanced solid tumors
Anthony W Tolcher, Michael Gordon, Kathleen M Mahoney, Anna Seto, Marianna Zavodovskaya, Chia-Hsiang Hsueh, Shuyan Zhai, Thomas Tarnowski, Juliane M Jürgensmeier, Susanna Stinson, Ahmed A Othman, Tianling Chen, James Strauss

Journal for ImmunoTherapy of Cancer Feb 2023, 11 (2) e005267; DOI: 10.1136/jitc-2022-005267
Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR
Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Hao Zhang, Wijnand Helfrich

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006837; DOI: 10.1136/jitc-2023-006837
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Kate Williamson, Hannah Buckley, Saadia A Karim, Matthew Wilson, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Frances M Richards, Richard Goodwin, Rebecca Brais, Jennifer P Morton, Simon J Dovedi, Alwin G Schuller, Jim Eyles, Duncan I Jodrell

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006457; DOI: 10.1136/jitc-2022-006457
Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation
Lydia Meziani, Marine Gerbé de Thoré, Céline Clémenson, Winchygn Liu, Pierre-Antoine Laurent, Michele Mondini, Marie-Catherine Vozenin, Eric Deutsch

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006846; DOI: 10.1136/jitc-2023-006846
CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models
Jian Ye, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Tara G Vrooman, Maggie L Lesch, Carl J Johnston, Edith M Lord, Brian A Belt, David C Linehan, Jim Eyles, Scott A Gerber

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006842; DOI: 10.1136/jitc-2023-006842
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy
Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Julie Pelletier, Jean Sévigny, Eva Tolosa, Christa E Müller

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e004660; DOI: 10.1136/jitc-2022-004660

Main menu

Adenosine

Pages

Log in using your username and password

Main menu

Log in using your username and password

You are here

Adenosine

Pages