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  • Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING

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Clinical/translational cancer immunotherapy
Original research
Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING

Authors

  • Liqun Wang Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, GermanyDepartment of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China PubMed articlesGoogle scholar articles
  • Ren Luo Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaFaculty of Biology, University of Freiburg, Freiburg, GermanyGerman Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, GermanyGerman Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Kateryna Onyshchenko Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, GermanyFaculty of Biology, University of Freiburg, Freiburg, GermanyGerman Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, GermanyGerman Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Xi Rao Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, GermanyGerman Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, GermanyGerman Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Meidan Wang Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, GermanyFaculty of Biology, University of Freiburg, Freiburg, Germany PubMed articlesGoogle scholar articles
  • Beatrice Menz Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, Germany PubMed articlesGoogle scholar articles
  • Simone Gaedicke Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, Germany PubMed articlesGoogle scholar articles
  • Anca-Ligia Grosu Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, GermanyGerman Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, GermanyGerman Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Elke Firat Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, Germany PubMed articlesGoogle scholar articles
  • Gabriele Niedermann Department of Radiation Oncology, University of Freiburg Faculty of Medicine, Freiburg, GermanyGerman Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, GermanyGerman Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Ren Luo; luorenbu{at}gmail.com; Dr Gabriele Niedermann; gabriele.niedermann{at}uniklinik-freiburg.de
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Citation

Wang L, Luo R, Onyshchenko K, et al
Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING
Journal for ImmunoTherapy of Cancer 2023;11:e006235. doi: 10.1136/jitc-2022-006235

Publication history

  • Accepted July 21, 2023
  • First published August 28, 2023.
Online issue publication 
August 28, 2023

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.