T cell Receptor - TCR

Regional distribution of HLA frequencies in the USA: implications for TCR-based therapies
Christian Roy, Tomasz Sewastianik, Ileana Saenz, Gregory J Opiteck, Sean Stagg, Martin Maiers, Dirk Nagorsen

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011441; DOI: 10.1136/jitc-2024-011441
PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation
Xinxin Xiong, Danyang Wang, Liping Xu, Siyu Chen, Jingjing He, Xiaomin Zhang, Ziqian Fang, Jianeng Zhang, Wende Li, Penghui Zhou

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e010966; DOI: 10.1136/jitc-2024-010966
Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire
Leonie Rosenberger, Leo Hansmann, Vasiliki Anastasopoulou, Steven P Wolf, Kimberley Drousch, Christina Moewes, Xinyi Feng, Guoshuai Cao, Jun Huang, Poh Yin Yew, Erlend Strønen, Taigo Kato, Naresha Saligrama, Johanna Olweus, Yusuke Nakamura, Gerald Willimsky, Thomas Blankenstein, Hans Schreiber, Matthias Leisegang

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011351; DOI: 10.1136/jitc-2024-011351
Tailoring CAR surface density and dynamics to improve CAR-T cell therapy
Ana Hinckley-Boned, Carmen Barbero-Jiménez, Maria Tristán-Manzano, Noelia Maldonado-Perez, Michael Hudecek, Pedro Justicia-Lirio, Francisco Martin

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010702; DOI: 10.1136/jitc-2024-010702
Shp-1 regulates the activity of low-affinity T cells specific to endogenous self-antigen during melanoma tumor growth and drives resistance to immune checkpoint inhibition
Joseph G Matous, Jeremy P Snook, Nico A Contreras, Andrew G Ramstead, Krystal R Charley, Elizabeth M Kolawole, Jacob N Kisiolek, Kaitlyn A Flint, Ashleigh J Soedel, Breyana Robinson, Anaiya B Mendoza, Yohichi Kumaki, Brian D Evavold, Matthew A Williams

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010879; DOI: 10.1136/jitc-2024-010879
Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy
Ryutaro Kajihara, Mark D Long, Toshifumi Hoki, Hongbin Chen, Takayoshi Yamauchi, Hisashi Kanemaru, Brahm H Segal, Grace K Dy, Fumito Ito

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010092; DOI: 10.1136/jitc-2024-010092
Leveraging mRNA technology for antigen based immuno-oncology therapies
Charalampos S Floudas, Siranush Sarkizova, Michele Ceccarelli, Wei Zheng

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010569; DOI: 10.1136/jitc-2024-010569
Utilization of primary tumor samples for cancer neoantigen discovery
Vid Leko, Eric Groh, Shoshana T Levi, Amy R Copeland, Bradley Sinclair White, Billel Gasmi, Yong Li, Victoria Hill, Devikala Gurusamy, Noam Levin, Sanghyun Peter Kim, Sivasish Sindiri, Jared J Gartner, Todd D Prickett, Maria Parkhust, Frank J Lowery, Stephanie L Goff, Steven A Rosenberg, Paul Robbins

Journal for ImmunoTherapy of Cancer Jan 2025, 13 (1) e010993; DOI: 10.1136/jitc-2024-010993
High peripheral T cell diversity is associated with lower risk of toxicity and superior response to dual immune checkpoint inhibitor therapy in patients with metastatic NSCLC
Mehmet Altan, Ruoxing Li, Ziyi Li, Runzhe Chen, Ajay Sheshadri, Hai T Tran, Latasha Little, Joshua Baguley, Jefferson Sinson, Natalie Vokes, Saumil Gandhi, Mara B Antonoff, Stephen G Swisher, Greg Lizee, Alexandre Reuben, John V Heymach, Jianjun Zhang

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e008950; DOI: 10.1136/jitc-2024-008950
Preclinical model for evaluating human TCRs against chimeric syngeneic tumors
Aikaterini Semilietof, Evangelos Stefanidis, Elise Gray-Gaillard, Julien Pujol, Alessia D'Esposito, Patrick Reichenbach, Philippe Guillaume, Vincent Zoete, Melita Irving, Olivier Michielin

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009504; DOI: 10.1136/jitc-2024-009504

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