systems biology

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy
Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008104; DOI: 10.1136/jitc-2023-008104
Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling
Kenichi Makino, Mark D Long, Ryutaro Kajihara, Satoko Matsueda, Takaaki Oba, Kazunori Kanehira, Song Liu, Fumito Ito

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003827; DOI: 10.1136/jitc-2021-003827
Gut microbiome-depleting antibiotic regimens are not tolerated by all mouse strains: learn from (our) bitter experience
Andrew A Almonte, George Cavic, Teresa Neeman, Anselm Enders, Aude M Fahrer

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005575; DOI: 10.1136/jitc-2022-005575
Virtual clinical trials of anti-PD-1 and anti-CTLA-4 immunotherapy in advanced hepatocellular carcinoma using a quantitative systems pharmacology model
Richard J Sové, Babita K Verma, Hanwen Wang, Won Jin Ho, Mark Yarchoan, Aleksander S Popel

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005414; DOI: 10.1136/jitc-2022-005414
Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity
Seemadri Subhadarshini, Sarthak Sahoo, Shibjyoti Debnath, Jason A Somarelli, Mohit Kumar Jolly

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006766; DOI: 10.1136/jitc-2023-006766
Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer
Hanwen Wang, Huilin Ma, Richard J Sové, Leisha A Emens, Aleksander S Popel

Journal for ImmunoTherapy of Cancer Feb 2021, 9 (2) e002100; DOI: 10.1136/jitc-2020-002100
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
Qi Wu, Ai-Ling Tian, Bei Li, Marion Leduc, Sabrina Forveille, Peter Hamley, Warren Galloway, Wei Xie, Peng Liu, Liwei Zhao, Shuai Zhang, Pan Hui, Frank Madeo, Yi Tu, Oliver Kepp, Guido Kroemer

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002722; DOI: 10.1136/jitc-2021-002722
Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy
Yixiao Zhang, Yuan Yao, Peng Chen, Yu Liu, Hao Zhang, He Liu, Yu Liu, Hong Xu, Xibao Tian, Zichu Wang, Peng Chu, Dongyu Zhao, Hongxu Liu, Chenlei Zhang, Shuyuan Chen, Yuhong Zhao, Caigang Liu, Yongliang Yang

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001247; DOI: 10.1136/jitc-2020-001247
Influence of gut microbiome on multiple myeloma: friend or foe?
Nausheen Ahmed, Mahmoud Ghannoum, Molly Gallogly, Marcos de Lima, Ehsan Malek

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000576; DOI: 10.1136/jitc-2020-000576

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systems biology