Monoclonal antibody

Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironment
Jenna H Rannikko, Rita Turpin, Pia Boström, Reetta Virtakoivu, Chantal Harth, Akira Takeda, Anselm Tamminen, Ilkka Koskivuo, Maija Hollmén

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e011292; DOI: 10.1136/jitc-2024-011292
CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity
Kerry A Whalen, Catherine C Henry, Naveen K Mehta, Kavya Rakhra, Safak Yalcin, Kristan Meetze, Neil W Gibson, Patrick A Baeuerle, Jennifer S Michaelson

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e008987; DOI: 10.1136/jitc-2024-008987
Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors
Melanie Grandits, Lais C G F Palhares, Gabriel Osborn, Jitesh Chauhan, Katie Stoker, Heng Sheng Sow, Rebecca Adams, Alex J McCraw, Alicia Chenoweth, Sofia Vlasova, Jacobo López-Abente, Kristina M Ilieva, James Birtley, Sophia Tsoka, Elizabeth Hardaker, Kevin FitzGerald, Sophia N Karagiannis, Heather J Bax

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010945; DOI: 10.1136/jitc-2024-010945
4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models
Eneko Garate-Soraluze, Irantzu Serrano-Mendioroz, Leticia Fernández-Rubio, Carlos E De Andrea, Celia Barrio-Alonso, Claudia del Pilar Herrero, Alvaro Teijeira, Carlos Luri-Rey, Christina Claus, Tamara Tanos, Christian Klein, Pablo Umana, Antonio Rullan, Jon Ander Simón, María Collantes, Paloma Sánchez-Mateos, Ignacio Melero, Maria E Rodriguez-Ruiz

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e009852; DOI: 10.1136/jitc-2024-009852
Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment
Nils Hansen, Pablo Peña-Martínez, Petter Skoog, Katrin Reinbach, Finja C Hansen, Susanne Larsson Faria, Caitríona Grönberg, Kawther Abdilleh, Susanne Magnusson, Karin von Wachenfeldt, Camilla Rydberg Millrud, David Liberg, Marcus Järås

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009523; DOI: 10.1136/jitc-2024-009523
Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors
Matthew H Taylor, Aung Naing, John Powderly, Paul Woodard, Luke Chung, Wen Hong Lin, Hongyu Tian, Nathan Siemers, Hong Xiang, Rong Deng, Kyu Hong, Donna Valencia, Tao Huang, Ying Zhu, X Charlene Liao, Xiao Min Schebye, Manish R Patel

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010006; DOI: 10.1136/jitc-2024-010006
Depletion of conventional CD4⁺ T cells is required for robust priming and dissemination of tumor antigen-specific CD8⁺ T cells in the setting of anti-CD4 therapy
Delaney E Ramirez, Christo P C Dragnev, Tyler G Searles, Nathaniel Spicer, Tiffany Chen, J Louise Lines, Aaron R Hawkes, Wilson L Davis, Asmaa Mohamed, Keisuke Shirai, Joseph D Phillips, Pamela C Rosato, Yina H Huang, Mary Jo Turk

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010170; DOI: 10.1136/jitc-2024-010170
TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment
Fadi Azar, Jules Deforges, Christelle Demeusoit, Patricia Kleinpeter, Christelle Remy, Nathalie Silvestre, Johann Foloppe, Laetitia Fend, Clémentine Spring-Giusti, Eric Quéméneur, Jean-Baptiste Marchand

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009302; DOI: 10.1136/jitc-2024-009302
rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors
Dan Li, Tianyuzhou Liang, Laura E Hutchins, Alexandra A Wolfarth, Sara Ferrando-Martinez, Byung Ha Lee, Mitchell Ho

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e008989; DOI: 10.1136/jitc-2024-008989
Generation of non-genetically modified, CAR-like, NK cells
Loïs Coënon, Emilie Rigal, Hortense Courot, Caroline Multrier, Sara Zemiti, Jennifer Lambour, Martine Pugnière, Marion de Toledo, Guillaume Bossis, Guillaume Cartron, Bruno Robert, Pierre Martineau, Bénédicte Fauvel, Jessy Presumey, Martin Villalba

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009070; DOI: 10.1136/jitc-2024-009070

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