Biomarker

Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings
Brian S Henick, Peter D Koch, Justin F Gainor, Mark M Awad, Codruta Chiuzan, Stephanie Izard, Yohanna Georgis, Samyukta Mallick, Robert F Garofano, Cheryl V Wong, Anjali Saqi, Jessica Grindheim, Katja Schulze, Joshua R Sonett, Naiyer A Rizvi, Benjamin Izar, Alison M Taylor, Catherine A Shu

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009301; DOI: 10.1136/jitc-2024-009301
Evaluation of immune checkpoint inhibitor efficacy for solid tumors with CD274 (PD-L1 gene) amplification identified by comprehensive genomic profiling: retrospective study based on a nationwide database
Tomohiro Nakayama, Takayuki Takahama, Yasutaka Chiba, Naoki Shiraishi, Hisato Kawakami, Kimio Yonesaka, Kazuhiko Nakagawa, Hidetoshi Hayashi

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e010130; DOI: 10.1136/jitc-2024-010130
Spatial patterns and MRI-based radiomic prediction of high peritumoral tertiary lymphoid structure density in hepatocellular carcinoma: a multicenter study
Shichao Long, Mengsi Li, Juan Chen, Linhui Zhong, Aerzuguli Abudulimu, Lan Zhou, Wenguang Liu, Deng Pan, Ganmian Dai, Kai Fu, Xiong Chen, Yigang Pei, Wenzheng Li

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e009879; DOI: 10.1136/jitc-2024-009879
Plasma arginine as a predictive biomarker for outcomes with immune checkpoint inhibition in metastatic colorectal cancer: a correlative analysis of the CCTG CO.26 trial
Lucy X Ma, Emma Titmuss, Jonathan M Loree, Derek J Jonker, Hagen F Kennecke, Scott Berry, Felix Couture, Chaudhary E Ahmad, John R Goffin, Petr Kavan, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Sheryl Koski, Dongsheng Tu, Christopher O’Callaghan, Eric X Chen

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e010094; DOI: 10.1136/jitc-2024-010094
Mutation-guided chemotherapy-free strategy in first-line immunotherapy for low PD-L1-expressing non-squamous NSCLC
Hui Li, Jingjing Liu, Liang Zhang, Yu Xu, Xinyue Wang, Shaowei Lan, Peng Cui, Guoqiang Wang, Shangli Cai, Ying Cheng

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009693; DOI: 10.1136/jitc-2024-009693
Antecedent viral immunization and efficacy of immune checkpoint blockade: an extensive serum antibody profile to predict outcomes in non-small cell lung cancer
Filippo G Dall’Olio, Wael Salem Zrafi, Quentin Blampey, Francois-Xavier Danlos, Matthieu Roulleaux-Dugage, Gabriel Roman, Charles Naltet, Paul-Henry Cournède, Daniel Gautheret, Mihaela Aldea, David Planchard, Fabrice Barlesi, Aurelien Marabelle, Tyler Hulett, Nathalie Chaput-Gras, Benjamin Besse

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009931; DOI: 10.1136/jitc-2024-009931
Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression
Amaia Martinez-Usatorre, Laura Ciarloni, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Eric Durandau, Sylvain Monnier-Benoit, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Mauro Delorenzi, Stephan Morgenthaler, Brian Hashemi, Noushin Hadadi, Sahar Hosseinian-Ehrensberger, Pedro J Romero

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009888; DOI: 10.1136/jitc-2024-009888
Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors
Matthew H Taylor, Aung Naing, John Powderly, Paul Woodard, Luke Chung, Wen Hong Lin, Hongyu Tian, Nathan Siemers, Hong Xiang, Rong Deng, Kyu Hong, Donna Valencia, Tao Huang, Ying Zhu, X Charlene Liao, Xiao Min Schebye, Manish R Patel

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010006; DOI: 10.1136/jitc-2024-010006
Myeloid subsets impede the efficacy of anti-PD1 therapy in patients with advanced gastric cancer (WJOG10417GTR study)
Hirokazu Shoji, Chie Kudo-Saito, Kengo Nagashima, Hiroshi Imazeki, Kai Tsugaru, Naoki Takahashi, Takeshi Kawakami, Yusuke Amanuma, Takeru Wakatsuki, Naohiro Okano, Yukiya Narita, Yoshiyuki Yamamoto, Rika Kizawa, Kei Muro, Kazunori Aoki, Narikazu Boku

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010174; DOI: 10.1136/jitc-2024-010174
Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study
Kevin C Flanagan, Jon Earls, Jeffrey Hiken, Rachel L Wellinghoff, Michelle M Ponder, Howard L McLeod, William H Westra, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Orlan K Macdonald, Karim Welaya, James Wade, Georges Azzi, Andrew W Pippas, Jennifer Slim, Bruce Bank, Xingwei Sui, Steven E Kossman, Todd D Shenkenberg, Warren L Alexander, Katharine A Price, Jessica Ley, David N Messina, Jarret I Glasscock, A Dimitrios Colevas, Ezra E W Cohen, Douglas Adkins, Eric J Duncavage

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009573; DOI: 10.1136/jitc-2024-009573

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