Antibody

Combinatorial treatment with upadacitinib abrogates systemic toxicity of a tumor-targeted IL-2 fusion protein
Giulia Rotta, Eleonora Prodi, Frauke Seehusen, Matilde Bocci, Francesco Prisco, Ettore Gilardoni, Claudia Comacchio, Cornelia Halin, Emanuele Puca, Dario Neri, Sheila Dakhel Plaza

Journal for ImmunoTherapy of Cancer May 2025, 13 (5) e010831; DOI: 10.1136/jitc-2024-010831
Siglec-15 antibody–GM-CSF chimera suppresses tumor progression via reprogramming tumor-associated macrophages
Zemeng Ma, Xiaoyao Hao, Shuang Qu, Quanli Zhang, Jiajing Luo, Hongyan Li, Jinyu Liu, Wenwen Dai, Jun Li, Shouyong Gu, Dihan Zhu, Mingjiu Chen, Ke Zen

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010580; DOI: 10.1136/jitc-2024-010580
MHC class II-mediated spontaneous rejection of breast carcinomas expressing model neoantigens
James William Jenkins, Alvaro Peña, Sarah A Castro, Michael J Hansen, Virginia P Van Keulen, Sean T Foster, Pablo E Rios-Cruz, Joshua Yakubov, Destin T Hinson, Samuel M Olivier, Kevin D Pavelko, Sara J Felts, Aaron J Johnson, Larry R Pease

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010434; DOI: 10.1136/jitc-2024-010434
Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockade
Marcel Arias-Badia, Chien-Chun Steven Pai, Yee May Lwin, PeiXi Chen, Aahir Srinath, Miho Tanaka, Emily Musser, Andrew Goodearl, Jacob V Gorman, Wendy Ritacco, Lawrence Fong

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010566; DOI: 10.1136/jitc-2024-010566
Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumors
Koichi Jinushi, Takuro Saito, Koji Kurose, Susumu Suzuki, Takashi Kojima, Taishi Takahara, Tomoki Makino, Tetsuya Ogawa, Hiroyoshi Nishikawa, Kazuhiro Kakimi, Shinsuke Iida, Jun Nakajima, Yuichiro Doki, Mikio Oka, Ryuzo Ueda, Hisashi Wada

Journal for ImmunoTherapy of Cancer Apr 2025, 13 (4) e010634; DOI: 10.1136/jitc-2024-010634
Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies
Julien Montorfani, Eric Hatterer, Laurence Chatel, Adeline Lesnier, Alizée Viandier, Bruno Daubeuf, Lise Nouveau, Pauline Malinge, Sebastien Calloud, Krzysztof Masternak, Walter Ferlin, Nicolas Fischer, Camilla Jandus, Limin Shang

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010650; DOI: 10.1136/jitc-2024-010650
Microbial Ecosystem Therapeutics 4 (MET4) elicits treatment-specific IgG responses associated with changes in gut microbiota in immune checkpoint inhibitor recipients with advanced solid tumors
Matthew K Wong, Giselle M Boukhaled, Eric Armstrong, Rachel Liu, Alya A Heirali, Noelle R Yee, Jinny Tsang, Pavlina Spiliopoulou, Pierre H H Schneeberger, Ben X Wang, Kyla Cochrane, Keith Sherriff, Emma Allen-Vercoe, Lillian L Siu, Anna Spreafico, Bryan Coburn

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010681; DOI: 10.1136/jitc-2024-010681
Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer
Oladapo O Yeku, Minal Barve, Winston W Tan, Judy Wang, Amita Patnaik, Patricia LoRusso, Debra L Richardson, Abdul Rafeh Naqash, Sarah K Lynam, Siqing Fu, Michael Gordon, Joleen Hubbard, Shivaani Kummar, Christos Kyriakopoulos, Afshin Dowlati, Marc Chamberlain, Ira Winer

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010959; DOI: 10.1136/jitc-2024-010959
Leveraging T cell co-stimulation for enhanced therapeutic efficacy of trispecific antibodies targeting prostate cancer
Yanping Sun, Linling Zhou, Xinyu Gu, Jiaqi Zhao, Jie Bi, Liqiang Pan

Journal for ImmunoTherapy of Cancer Mar 2025, 13 (3) e010140; DOI: 10.1136/jitc-2024-010140
Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis
Chenyue Wang, Lisha Wu, Xingxing Li, Shuyang Mao, Zitong Wang, Haiyan Xie, Jing Xu, Danfang Li, Hao Yang, Tong Wang, Qingqing Huang, Lin Yang, Xiaofei Zhang, Yuxia Liu, Jin Wang, Gang Huang, Wei Xie

Journal for ImmunoTherapy of Cancer Feb 2025, 13 (2) e009621; DOI: 10.1136/jitc-2024-009621

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