Best overall response

a
	DL 14 mg/kgN = 3	DL 28 mg/kgN = 3	DL 316 mg/kgN = 3	DL 432 mg/kgN = 6	OverallN = 15
Stable disease (N, %)	3 (100%)	2 (67%)	2 (67%)	4 (67%)	11 (73%)
Progressive disease (N, %)	0 (0%)	1 (33%)	1 (33%)	2 (33%)	4 (27%)
b
Patient #	Tumor type	Dose (mg/kg)	Time on study (months)*	Best response	Off treatment reason	IL-8 level decrease
1	Colorectal	4	3.5	SD	Patient choice
2	Prostate	4	2	SD	Patient choice	x
3	Chordoma	4	8	SD	Patient choice
4	Chordoma	8	13	SD	Patient choice
5	Colorectal	8	1.5	PD	Progression
6	Esophageal	8	7	SD	Progression	x
7	Chondrosarcoma	16	1	PD	Progression	x
8	Chordoma	16	5.5	SD	Progression
9	Chordoma	16	5.5	SD	Patient choice	x
10	Papillary thyroid	32	5.5	SD	Patient choice	x
11	Colorectal	32	4.5	SD	Patient choice	x
12	Prostate	32	8	SD	Patient choice	x
13	Colorectal	32	7	SD	Patient choice	x
14	Ovarian	32	1.5	PD	Progression	x
15	Chordoma	32	2	PD	Progression	x

Best overall response. a Best overall response by dose level and overall are shown. b Responses are shown by tumor type and dose level in addition to time on study and reason for withdrawal from study treatment. Three patients had adverse events leading to their decision to come off the study. Decreases in IL-8 are also noted

DL dose level; IL-8 interleukin-8; SD stable disease; PD progressive disease