Current Issue

Basic and translational cancer immunology

• Original research: Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment (19 May, 2025)

  Oscar Badillo-Godinez, Jenni Niemi, Liam Helfridsson, Shokoufeh Karimi, Mohanraj Ramachandran, Hitesh Bhagavanbhai Mangukiya, Sven Nelander, Mats Hellström
• Original research: Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironment (15 May, 2025)

  Jenna H Rannikko, Rita Turpin, Pia Boström, Reetta Virtakoivu, Chantal Harth, Akira Takeda, Anselm Tamminen, Ilkka Koskivuo, Maija Hollmén
• Original research: Sensitivity to immune checkpoint inhibitors in BRAF/MEK inhibitor refractory melanoma (15 May, 2025)

  Riyaben P Patel, Lydia Rui Jia Lim, Reem Saleh, Darius Schenk, Michael K Lee, Emily Lelliott, Aparna D Rao, Shaghayegh Arabi, Lorey Smith, Anna S Trigos, Nicole Haynes, Grant A McArthur, Karen E Sheppard
• Original research: Combination of a therapeutic cancer vaccine targeting the endogenous retroviral envelope protein ERVMER34-1 with immune-oncology agents facilitates expansion of neoepitope-specific T cells and promotes tumor control (13 May, 2025)

  Maria del Mar Maldonado, Maria Gracia-Hernandez, Loc Huu Le, Masafumi Iida, James L Gulley, Renee N Donahue, Claudia Palena, Jeffrey Schlom, Duane H Hamilton
• Original research: Early dynamics of clinical and laboratory parameters predict primary refractory disease in patients with metastatic urothelial carcinoma receiving atezolizumab (7 May, 2025)

  Christopher J Graser, Thomas O McDonald, Paul J Catalano, Guru Sonpavde, Franziska Michor
• Original research: Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models (7 May, 2025)

  Jian Ye, Shuyang S Qin, Angela L Hughson, Gary Hannon, Noah A Salama, Tara G Vrooman, Maggie L Lesch, Sidney Lesser, Sarah L Eckl, Rachel Jewell, Lauren Benoodt, Bradley N Mills, Carl J Johnston, Edith Lord, Brian A Belt, Laura M Calvi, David Linehan, Nadia Luheshi, Jim Eyles, Scott A Gerber
• Original research: PD-1 blockade employed at the time CD8+ T cells are activated enhances their antitumor efficacy (7 May, 2025)

  Jena E Moseman, Ichwaku Rastogi, Donghwan Jeon, Douglas G McNeel
• Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire (2 May, 2025)

  Leonie Rosenberger, Leo Hansmann, Vasiliki Anastasopoulou, Steven P Wolf, Kimberley Drousch, Christina Moewes, Xinyi Feng, Guoshuai Cao, Jun Huang, Poh Yin Yew, Erlend Strønen, Taigo Kato, Naresha Saligrama, Johanna Olweus, Yusuke Nakamura, Gerald Willimsky, Thomas Blankenstein, Hans Schreiber, Matthias Leisegang
• Combination of HDAC inhibition and cytokine enhances therapeutic HPV vaccine therapy (2 May, 2025)

  Lisa K Poppe, Nicholas Roller, Miriam Marlene Medina-Enriquez, Wiem Lassoued, Daniel Burnett, Katherine E Lothstein, Asma S Khelifa, Masaya Miyamoto, James L Gulley, Caroline Jochems, Jeffrey Schlom, Sofia R Gameiro
• RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity (2 May, 2025)

  Hui Guo, Jie Hu, Zining Wang, Feifei Xu, Yongxiang Liu, Lei Cui, Huanling Zhang, Chunyuan Xie, Ruhui Yao, Huan Jin, Zixuan Guo, Tiantian Wang, Lin Li, Yanxun Lin, Xiaojuan Wang, Heping Li, Xiaojun Xia